<P>A general class of powerful and flexible modeling techniques, spline smoothing has attracted a great deal of research attention in recent years and has been widely used in many application areas, from medicine to economics. <STRONG>Smoothing Splines: Methods and Applications</STRONG> covers basic smoothing spline models, including polynomial, periodic, spherical, thin-plate, L-, and partial splines, as well as more advanced models, such as smoothing spline ANOVA, extended and generalized smoothing spline ANOVA, vector spline, nonparametric nonlinear regression, semiparametric regression, and semiparametric mixed-effects models. It also presents methods for model selection and inference.</P><br/><br/><P></P><br/><br/><P>The book provides unified frameworks for estimation, inference, and software implementation by using the general forms of nonparametric/semiparametric, linear/nonlinear, and fixed/mixed smoothing spline models. The theory of reproducing kernel Hilbert space (RKHS) is