<B>The astonishing true story of how Catherine the Great joined forces with a Quaker doctor from Essex to spearhead one of the first global public health campaigns.</B><BR><BR><B>A <I>TIMES</I> BEST BOOK OF 2022 SO FAR</B><BR><BR><B>Shortlisted for the Pushkin House Book Prize 2022</B><BR><BR><B>‘Sparkling history…with a fairytale atmosphere of sleigh rides, royal palaces and heroic risk-taking’ <I>The Times</I></B><BR><BR><B>A killer virus…an all-powerful Empress…an encounter cloaked in secrecy…the astonishing true story.</B><BR><BR>Within living memory, smallpox was a dreaded disease. Over human history it has killed untold millions. Back in the eighteenth century, as epidemics swept Europe, the first rumours emerged of an effective treatment: a mysterious method called inoculation.<BR><BR>But a key problem remained: convincing people to accept the preventative remedy, the forerunner of vaccination. Arguments raged over risks and benefits, and