<P>Coordination compounds have been well-known for their wide variety of applications for over a century, as well as enhancing the researcher¿s interest and concern in evaluating their action mechanism. It is certainly one of the most intensely discussed research topics. Coordination compounds involve different metal-ion-ligand phenomenon. The involved metal ions play a significant role in structural association and functioning of several processes in the genetic and metabolism system. </P><P>In recent years, Schiff base ligands have gained significant interest and received a keen interest of many researchers. Schiff¿s base ligands have been recognized to hold a wide variety of biological and medicinal activities due to the presence of donor atoms. They have proved exceptional pharmalogical actions such as antimicrobial, anti-tuberclosis, antiplatelet, antidiabetic, antiarthritis, antioxidant, anti-inflammatory, anticancer, antiviral, antimalarial, and analgesic. These biologically act