Pathophysiology - what is the cause? <p>Clinical significance - what does it mean?</p><p>Diagnosis and treatment - what is the predictive value?</p><p>These are questions that all clinicians should continue to ask themselves from the very beginning of medical training and throughout a lifetime of practice.</p><p>Organised by body system, <i>Mechanisms of Clinical Signs 3e</i> describes the underlying pathway, differential diagnoses and value of the clinical signs seen during physical examination.</p>