Drug-Like Properties av Li (Pfizer East Lyme CT USA) Di, Edward H (National Institutes of Health Bethesda MD USA) Kerns

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<p>Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. <i>Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition,</i> provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those fo