Current Topics in Nonclinical Drug Development

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<P>The second volume in the <I>CURRENT TOPICS IN NONCLINICAL DRUG DEVELOPMENT SERIES</I> explores the critical issues and current topics in nonclinical drug development. This second volume covers individual topics and strategies in drug development from compound characterization to drug registration. Written by a variety of experts in the field, recent and rapid advances in technologies and associated changes in regulatory guidance are discussed.</P><P>Select topics include:</P><UL><LI>Evolution of Artificial Intelligence (AI) technologies and the impact on toxicologic pathology.</LI><LI>Current approaches to carcinogenicity testing.</LI><LI>Predicting drug-drug interactions.</LI><LI>Current understanding of idiosyncratic drug reaction.</LI><LI>Assessing cardiovascular risks beyond QT interval.</LI><LI>Use of 3D cell cultures in toxicology and ADME.</LI><LI>Development of small molecule-antibody complexes.</LI><LI>Differentiating adverse from non-adverse findings in nonclinical studies