Concepts and Models for Drug Permeability Studies av Bruno (Affiliated Investigator INEB¿Instituto de Engenharia Biomedica University of Porto Portuga

1975,-

Kjøp

<p><i>Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, </i>Second Edition, summarizes the most important developments in in vitro models for predicting the permeability of drugs. This book is structured around three different approaches, summarizing the most recent achievements regarding models comprising (i) immortalized cells with an intrinsic ability to grow as monolayers when seeded in permeable supports, (ii) primary cells isolated from living organisms and directly cultured as barrier monolayers, and (iii) tissue-based models constructed with cell lines and extracellular matrix that resembles the tridimensional structure of mucosae and other biological membranes, or animal/patient-derived tissues. Each model is covered in detail, including the protocol of generation and application for specific drugs/drug delivery systems. The equivalence between in vitro cell and tissue models and in vivo conditions is discussed, highlighting how