<P>A new era of complexity science is emerging, in which nature- and bio-inspired principles are being applied to provide solutions. At the same time, the complexity of systems is increasing due to such models like the Internet of Things (IoT) and fog computing. Will complexity science, applying the principles of nature, be able to tackle the challenges posed by highly complex networked systems?</P><P><STRONG><EM>Bio-Inspired Optimization in Fog and Edge Computing: Principles, Algorithms, and Systems</EM></STRONG> is an attempt to answer this question. It presents innovative, bio-inspired solutions for fog and edge computing and highlights the role of machine learning and informatics. Nature- or biological-inspired techniques are successful tools to understand and analyze a collective behavior. As this book demonstrates, algorithms, and mechanisms of self-organization of complex natural systems have been used to solve optimization problems, particularly in complex systems that are adap