<p><i>A First Course in Systems Biology</i> is an introduction to the growing field of systems biology for advanced undergraduates and graduate students. Its focus is the design and analysis of computational models and their applications to diverse biomedical phenomena, from simple networks and kinetics to complex pathway systems, signal transduction, personalized medicine, and interacting populations. The book begins with the fundamentals of computational modeling, then reviews features of the molecular inventories that bring biological systems to life, and ends with case studies that reflect some of the frontiers in systems biology. In this way, the <i>First Course</i> provides the reader with a comprehensive background and with access to methods for executing standard tasks of biomedical systems analysis, exposure to the modern literature, and a foundation for launching into specialized projects that address biomedical questions with theoretical and computational means. <br/><br/>